货号：559047

品牌：BD Pharmingen

规格：1EA

目录价：￥5662.00

市场价格：￥3567.06

会员价格：￥3114.10

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Catalog Number

559047

Brand

BD Pharmingen™

Name

CD54

Alias

ICAM-1

Concentration

1.0 mg/ml

Size

0.2mg

RegulatoryStatus

RUO

Clone

LB-2

Format

Purified

Isotype

IgG_2b, κ

W.S. No

IV B50, M165

W.B. Positive Control

none

Immunogen

Major histocompatibility Class II antigen negative variant of human B-lymphoblastoid cell line

Reactivity

QC Testing : Human

Applications

Flow cytometry	- Routinely Tested
Functional assay	- Reported
Immunohistochemistry	- Reported
Immunoprecipitation	- Reported

Clone - Description

CD54 recognizes the intercellular adhesion molecule (ICAM-1), Mr 90kDa. The CD54 antigen is a ligand for the leucocyte function–associated antigen-1 (CD11a/CD18 [LFA-1]) and influences both LFA-1–dependent adhesion of leucocytes to endothelial cells and immune functions involving cell-to-cell contact.In peripheral blood, the CD54 antigen is weakly expressed on peripheral blood leucocytes. The amount of antigen expression on resting peripheral blood lymphocytes is highly variable. Upon activation by mitogens, the antigen becomes strongly expressed on B and T lymphocytes, macrophages, and granulocytes. The CD54 antigen is also inducible on fibroblasts, epithelial cells, and endothelial cells. In addition, the antigen has been shown to be the receptor for most human rhinoviruses (the major cause of the common cold).In normal tissue, CD54 antigen density is highest in endothelium and is increased by factors such as exposure to cytokines, inflammation, and neoplastic transformation. The antigen is strongly expressed on macrophages and on B lymphocytes in the germinal center.