货号：558695

品牌：BD Pharmingen

规格：1EA

目录价：￥4503.00

市场价格：￥2836.89

会员价格：￥2476.65

金山科研平台，产品价格货期咨询微信：jinshanbio

The 3/23 clone reacts with CD40, a 40-50 kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. CD40 has been reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react with 5-10% of T lymphocytes in adult mouse, but not neonatal, spleen. CD40 plays a key role in B-cell growth and differentiation where interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses. In addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells. Ligation of CD40 with the 3/23 antibody has been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2). In addition, although the 3/23 antibody by itself is a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell proliferation.

Catalog Number

558695

Brand

BD Pharmingen™

Name

CD40

Concentration

0.2 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

3/23

Format

APC

Isotype

IgG_2a, κ

W.B. Positive Control

none

Immunogen

Mouse CD40 Recombinant Protein

Strain Host

LOU

Reactivity

QC Testing : Mouse

Applications

Flow cytometry

- Routinely Tested