货号：558694

品牌：BD Pharmingen

规格：1EA

目录价：￥5075.00

市场价格：￥3197.25

会员价格：￥2791.25

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Reacts with the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD2791 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate na�ve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

Catalog Number

558694

Brand

BD Pharmingen™

Name

CD279

Alias

PD-1

Size

100Tests

RegulatoryStatus

RUO

Clone

MIH4

Format

APC

Isotype

IgG₁, κ

W.B. Positive Control

none

Immunogen

Human PD-1 Transfected Cell Line

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested