货号：558570

品牌：BD Pharmingen

规格：1EA

目录价：￥4033.00

市场价格：￥2540.79

会员价格：￥2218.15

金山科研平台，产品价格货期咨询微信：jinshanbio

The monoclonal antibody BB7.2 reacts with a subunit of the human leukocyte antigen-A2 (HLA-A2), a class I molecule of the major histocompatibility complex (MHC). The MHC gene locus encodes a group of highly polymorphic, cell-surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Human (human leukocyte antigen/HLA) MHC molecules comprise two major classes, MHC class I and class II. Functionally, class I MHC molecules can bind peptides derived from intracellular antigens (eg, viral and some bacterial antigens) that are specifically recognized by CD8+ T cells, and class II MHC molecules recognize antigens derived from pathogens multiplying in intracellular vesicles, and those derived from ingested extracellular bacteria. When presented on the cell surface by the MHC class II molecules, these antigens are recognized by CD4+ T cells. TCR recognize both processed peptides bound to MHC, as well as regions of the MHC molecule itself. CD4 and CD8 accessory molecules strengthen formation of the TCR-MHC complex through their interaction with non-polymorphic regions of the MHC molecule.

Catalog Number

558570

Brand

BD Pharmingen™

Name

HLA-A2

Size

100Tests

RegulatoryStatus

RUO

Clone

BB7.2

Format

PE

Isotype

IgG_2b, κ

W.B. Positive Control

none

Reactivity

QC Testing : Human

Applications

Blocking	- Reported
Flow cytometry	- Routinely Tested