货号：558561

品牌：BD Pharmingen

规格：50Tst

目录价：￥3920.00

市场价格：￥2469.60

会员价格：￥2156.00

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The membrane associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src-transformed cells. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate b-catenin and g-catenin proteins in its 42-amino acid Arm domain. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like b- and g-catenin, p120 catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain. It exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S873), and threonine (T310 and T910) residues in p120 catenin may regulate its activity. The S873 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b. Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation.The 17/catenin monoclonal antibody recognizes the phosphorylated S288 in the regulatory domain of p120 catenin.

Catalog Number

558561

Brand

BD Phosflow™

Name

p120 Catenin (pS288)

Size

50Tests

RegulatoryStatus

RUO

Clone

17/catenin

Format

Alexa Fluor® 647

Isotype

IgG_2a

W.B. Positive Control

none

Molecular Weight

120 kDa

Immunogen

Phosphorylated Human P120 Catenin Peptide

Aliases

cl.17

Reactivity

QC Testing : HumanTested in Development : Mouse

Applications

Intracellular staining (flow cytometry)

- Routinely Tested