货号：558525

品牌：BD Pharmingen

规格：50Tst

目录价：￥3769.00

市场价格：￥2374.47

会员价格：￥2072.95

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The members of the Mitogen-Activated Protein Kinase (MAPK) family are components of a key signal transduction cascade that links events at the cell surface to responses in the nucleus. The signaling cascade is found in species as varied as yeast and humans, with many of the proteins being well conserved. In mammals the most widely studied members of the cascade are the Extracellular signal-Regulated Kinases, ERK1 (p44 MAPK) and ERK2 (p42 MAPK). ERK1 and ERK2 share 85% homology and are activated by extracellular signals such as growth factors, hormones, and phorbol esters. Activation occurs through a series of phosphorylations by kinases activating other kinases and eventually leading to phosphorylation of the ERKs. Growth factor stimulation leads to activation of Ras and Raf, leading to phosphorylation of MEK1 (MAPK/ERK kinase) which, in turn, activates the ERKs via dual phosphorylation. Once activated, the ERKs phosphorylate other cytoplasmic signalling molecules (protein kinases and phosphatases), cell-surface receptors, microtubule-associated proteins, and transcription factors in the nucleus. Thus, the active ERK has myriad downstream effectors that implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Furthermore, studies have shown that elevated ERK activity is associated with some cancers.The G263-7 monoclonal antibody recognizes human and mouse ERK2, regardless of phosphorylation status. It does not cross-react with ERK1.

Catalog Number

558525

Brand

BD Phosflow™

Name

ERK2

Size

50Tests

RegulatoryStatus

RUO

Clone

G263-7

Format

Alexa Fluor® 488

Isotype

IgG₁, κ

W.S. No

none

W.B. Positive Control

RSV-3T3

Molecular Weight

42 kDa

Immunogen

Human ERK2 Synthetic Peptide

Reactivity

QC Testing : HumanReported : Mouse

Applications

Intracellular staining (flow cytometry)

- Routinely Tested