货号：558523

品牌：BD Pharmingen

规格：1EA

目录价：￥4378.00

市场价格：￥2758.14

会员价格：￥2407.90

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Epidermal Growth Factor (EGF) elicits a variety of cellular responses that are initiated by EGF Receptor (EGFR) binding and activation of intrinsic tyrosine kinase activity. EGFR, also known as ErbB1 or HER1, is a member of the ErbB class of receptor protein tyrosine kinases. It has an extracellular ligand-binding domain, a single transmembrane region, and a cytoplasmic region containing a protein tyrosine kinase domain and a c-terminal regulatory domain with many phosphorylation sites. Following ligand binding, EGFR forms homodimers and heterodimers with ErbB2. Specific C-terminal tyrosine residues are then autophosphorylated and, in turn, bind to adaptor proteins, kinases, or protein tyrosine phosphatases. In addition, c-Src-dependent phosphorylations at other sites, such as tyrosine 845 (Y845) in the kinase domain, regulate the receptor’s kinase activity. Inappropriate expression or mutations of EGFR and/or deregulation of its signaling pathways are associated with many types of cancer, making EGFR a promising target for cancer therapies.The 12A3 monoclonal antibody recognizes the phosphorylated Y845 in the protein tyrosine kinase domain of human EGFR.

Catalog Number

558523

Brand

BD Phosflow™

Name

EGF Receptor (pY845)

Size

50Tests

RegulatoryStatus

RUO

Clone

12A3

Format

Alexa Fluor® 647

Isotype

IgG₁, κ

W.B. Positive Control

none

Molecular Weight

175 kDa

Immunogen

Phosphorylated Human EGF Receptor Peptide

Reactivity

QC Testing : HumanReported : MouseReported : Rat

Applications

Intracellular staining (flow cytometry)

- Routinely Tested