货号：558515

品牌：BD Pharmingen

规格：50T

目录价：￥4378.00

市场价格：￥2758.14

会员价格：￥2407.90

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The 70-kDa z chain-associated protein (ZAP70) is a Syk-family protein tyrosine kinase (PTK) that associates with the z subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation. ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus. TCR-mediated Lck activity leads to phosphorylation of ZAP70 on Tyrosine 493 in the regulatory loop of the PTK domain leading to upregulation of ZAP70 kinase activity. Tyrosine 292 (Y292), in the linker region between the SH2 and PTK domains, is autophosphorylated by the activated PTK domain. By binding with c-Cbl, the phosphorylated Y292 can down-regulate TCR signaling.The J34-602 antibody recognizes ZAP70 phosphorylated at Y292.

Catalog Number

558515

Brand

BD Phosflow™

Name

Zap70 (pY292)

Size

50Tests

RegulatoryStatus

RUO

Clone

J34-602

Format

Alexa Fluor® 647

Isotype

IgG₁, κ

W.B. Positive Control

none

Molecular Weight

70 kDa

Immunogen

Phosphorylated Human ZAP70

Strain Host

BALB/c

Reactivity

QC Testing : Human

Applications

Intracellular staining (flow cytometry)

- Routinely Tested