货号：558486

品牌：BD Pharmingen

规格：1EA

目录价：￥4086.00

市场价格：￥2574.18

会员价格：￥2247.30

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The T cell receptor (TCR), expressed by thymocytes and T lymphocytes, is a multi-component cell-surface complex responsible for recognizing antigen in the context of MHC molecules. The antigen-specific binding component of the TCR, Ti, is a heterodimer of the variable Ig-like subunits a and b or g and d. Ti is non-covalently associated with an invariant set of molecules referred to as the CD3 polypeptides, g, d, e, and z. The CD3 z polypeptide (CD3z) was named CD247 at the 7th Human Leukocyte Differentiation Antigens Workshop. CD3 appears early in thymocyte differentiation and remains expressed on all mature T lymphocytes. After antigen recognition by the TCR, CD3z is the primary intracellular signal transducing subunit. It contains three ITAMs (Immunoreceptor Tyrosine-based Activation Motifs), each of which contains a pair of tyrosine residues that are phosphorylated by Lck and Fyn and are required for signal propagation. The molecular weight of CD3z is 16 kDa, and it is also observed as 32-kDa homodimers or as heterodimers with the g chain of Fc receptors. Upon phosphorylation, the CD3z monomer undergoes an apparent shift in electrophoretic mobility up to 21 kDa. The K25-407.69 monoclonal antibody recognizes the phosphorylated tyrosine 142 (pY142) in the third ITAM domain of human CD3z (CD247).

Catalog Number

558486

Brand

BD Phosflow™

Name

CD247 (pY142)

Alias

CD3ζ

Size

50Tests

RegulatoryStatus

RUO

Clone

K25-407.69

Format

Alexa Fluor® 488

Isotype

IgG_2a, κ

W.B. Positive Control

none

Molecular Weight

21 kDa

Immunogen

Phosphorylated Human CD3ζ Peptide

Reactivity

QC Testing : HumanPredicted : MousePredicted : Rat