金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: MRGX2 Long Name: Mas-related G Protein-coupled Receptor Member X2 Aliases: MRGPRX2 Entrez Gene IDs: 117194 (Human); 243978 (Mouse) Background: MRGX2 MRGX2 (MAS-related GPR, member X2) is G-protein coupled 7-transmembrane protein that is selectively expressed in small-diameter sensory neurons of dorsal root ganglia. Human MRGX shares 41-52% amino acid identity with three other primate MRGX proteins, but has no ortholog in rodents. Binding of ligands such as cortistatin, proadrenaomedullin peptides (PAMP-12 and -20) and basic peptides (substance P, neuropeptide Y) to MRGX2 can activate Gq or Gi regulated pathways. MRGX2 is thought to influence nociception and promote adrenal gland catecholamine secretion and IgE-independent mast cell degranulation.