货号：ABE239

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JARID1B Antibody | ABE239 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes JARID1B at the C-terminal domain. View All» Molecular Weight: ~180 kDa observed. Uncharacterized bands may be observed at ~ 48 and 53 kDa in some lysates. View All» Epitope: C-terminal domain View All» Immunogen: GST-tagged recombinant protein corresponding to human JARID1B at the C-terminal domain. View All» Background Information: JARID1B (jumonji AT rich interactive domain 1B), also known as KDM5B, is histone demethylase with a preference for mono, di, and trimethylated lysine 4 of histone H3. Demethylation of lysine 4 in histone 3 is commonly associated with transcriptional repression. This nuclear protein belongs to the ARID family of DNA binding proteins and is highly expressed in a large number of breast cancers. This protein has been linked to the repressinion of multiple tumor suppressor genes including BRCA1 and HOXA5. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunoprecipitation: A representative lot of this antibody was reported to work for immunoprecipitation analysis in Saos-2, MCF-7, and T47D lysates (Laboratory of E. Benevolenskaya , University of Illinois at Chicago). View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected JARID1B on 10 µg of A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9UGL1 View All» Entrez Gene Number: NP_006609 View All» Gene Symbol:

• CT31

• PLU-1

• RBBP2H1A

• PLU1

• JARID1B

• RBP2-like

• RBP2-H1

• PUT1

• RBBP2H1

• KDM5B
  View All» Alternate Names:
  • JMJD

  • lysine (K)-specific demethylase 5B

  • Jumonji, AT rich interactive domain 1B (RBP2-like)

  • putative DNA/chromatin binding motif

  • jumonji, AT rich interactive domain 1B

  • Histone demethylase JARID1B

  • retinoblastoma-binding protein 2, homolog 1A

  • Cancer/testis antigen 31

  • Jumonji/ARID domain-containing protein 1B

  • lysine-specific demethylase 5B

  • Retinoblastoma-binding protein 2 homolog 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).SUBUNIT STRUCTURE: Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7 (By similarity). SUBCELLULAR LOCATION: Nucleus TISSUE SPECIFICTY: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). DOMAIN: Both the JmjC domain and the JmjN domain are required for enzymatic activity.The 2 first PHD-type zinc finger domains are required for transcription repression activity.SEQUENCE SIMILARITIES: Belongs to the JARID1 histone demethylase family.Contains 1 ARID domain.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 3 PHD-type zinc fingers.SEQUENCE CAUTION: The sequence CAB63108.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-JARID1B View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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