货号：ABE108

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pygo1 Antibody | ABE108 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~49 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Pygopus homolog 1. View All» Background Information: Wnt/Wingless signaling controls many fundamental processeses, such as cellular growth and fate, and is known to be involved in embryonic segmentation, limb development and CNS patterning. Wnt signaling is also shown to influence postembryonic regulation of stem cell numbers and stem cell differentiation in epithelia, such as those of the colon and skin.Wnt transduction is mediated by the association of Beta-Catenin with nuclear TCF DNA binding factors, including legless (lgs) and pygopus (pygo). Whereas lgs enclodes BCL9, pygo encodes a Pygopus (Pygo), a PHD finger protein. It is reported that BCL9 acts as an adaptor protein that recruits and physically links Pygo to the Beta-Catenin-TCF Complex. It is demonstrated that the recruitment of Pygo is required for this respective complex to function as a transcriptional co-activator of specific target genes. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, Rat. Predicted to react with Chimpanzee and Rhesus Macaque based on 100% sequence homology. View All» Control: Human placenta tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in human placenta tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Pygo1 in human placenta tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y3Y4 View All» Entrez Gene Number: NP_056432.1 View All» Gene Symbol: PYGO1 View All» Alternate Names: Pygopus homolog 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Involved in signal transduction through the Wnt pathway.SUBUNIT STRUCTURE: Binds to BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1.SUBCELLULAR LOCATION: Nucleus. View All» Product Name: Anti-Pygo1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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