货号：ABE102

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SIRT6 Antibody | ABE102 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SIRT6 at the C-terminus. View All» Molecular Weight: ~32 kDa observed. There are three isoforms at 31, 36, and 39 kDa. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human SIRT6. View All» Background Information: SIRT6 is one of seven mammalian homologs of the yeast Sir2 histone deacetylase. SIRT6 is a nuclear, chromatin-associated protein that is very important in normal DNA repair and resistance to DNA damage. SIRT6-deficient mice develop severe abnormalities that seem to be closely related to models of normal aging-associated degeneration and die at 4 weeks. SIRT6 has also been associated with other aging-related pathways and may be responsible for normal longevity and homeostasis. Recently, SIRT6 has also been shown to play an important role in glucose metabolism. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected SIRT6 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N6T7 View All» Entrez Gene Number: NP_057623 View All» Gene Symbol:
  • SIRT6

  • SIR2L6
    View All» Alternate Names:
    • NAD-dependent deacetylase sirtuin-6

    • SIR2-like protein 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein By similarity. CATALYTIC ACTIVITY: NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SUBUNIT STRUCTURE: Interacts with RELA. SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Note: Predominantly nuclear. Associated with telomeric heterochromatin regions. SEQUENCE SIMILARITIES: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.SEQUENCE CAUTION: The sequence AAC34468.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAD15478.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAH04218.1 differs from that shown. Reason: Frameshift at position 23. View All» Product Name: Anti-SIRT6 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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