货号：ABD10

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MSX1 (Msh homeobox 1-like protein) Antibody | ABD10 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~31 kDa observed. An uncharacterized band appears at ~65 kDa in some lysates. View All» Immunogen: Linear peptide corresponding to human MSX1. View All» Background Information: The Msx genes are a family of homeobox genes related to the Drosophila msh (muscle segment homeobox)-like gene family. It may play a role in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations associated with MSX1 are tooth agenesis selective type 1, Witkop syndrome, and cleft lip. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. View All» Control: Human fetal skeletal muscle tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected MSX1 on 10 µg of human fetal skeletal muscle tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P28360 View All» Entrez Gene Number: NP_002439 View All» Gene Symbol:
  • MSX1

  • HOX7
    View All» Alternate Names:
    • Homeobox protein MSX-1

    • Homeobox protein Hox-7

    • Msh homeobox 1-like protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Expressed in the developing nail bed mesenchyme. PTM: Sumoylated by PIAS1, desumoylated by SENP1 (By similarity).INVOLVEMENT IN DISEASE: Defects in MSX1 are the cause of tooth agenesis selective type 1 (STHAG1) [MIM:106600]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Tooth agenesis selective type 1 can be associated with orofacial cleft in some patients. Note=MSX1 is deleted in some patients with Wolf-Hirschhorn syndrome (WHS). WHS results from sub-telomeric deletions in the short arm of chromosome 4.Defects in MSX1 are the cause of Witkop syndrome (WITS) [MIM:189500]. WITS is a form of ectodermal dyslasia also called tooth-and-nail syndrome or dysplasia of nails with hypodontia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Witkop syndrome is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. SEQUENCE SIMILARITIES: Belongs to the Msh homeobox family.Contains 1 homeobox DNA-binding domain.SEQUENCE CAUTION: The sequence AAH21285.4 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-MSX1 (Msh homeobox 1-like protein) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：http://16ao.com/thread-158838.htm
      © Merck Millipore代理ABD10 Anti-MSX1 (Msh homeobox 1-like protein)，产品报价联系微信jinshanbio