货号：AB1520

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glutamate Transporter Antibody, neuronal | AB1520 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neuronal Glutamate Transporter (EAAC1; also called EAAT3). The antibody has been tested on central nervous system tissue. The staining pattern for the cell bodies obtained with AB1520 corresponds to the pattern described using in situ hybridization with probes to rEAAC1 mRNA. The immunoreactivity corresponds to what has been described for glutamatergic neuronal systems. Preabsorption of the antiserum with the immunogen peptide completely abolishes the immunostaining. View All» Immunogen: Synthetic peptide from the carboxy-terminus of the cloned rat EAAC1. View All» Species Reactivity:

• Guinea Pig

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry: 1:4,000-8,000 using a cyanine-conjugated secondary antibody. Enzymatic methods of detections can be used, however antibody dilution must be increased to 1:10,000-1:30,000. Lightly fixed, 4% PFA material is recommended. The use of triton X-100 in the block only is recommended. This antibody is not recommended for use in Western blot. Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended: Western Blotting View All» Presentation: Goat antiserum. Liquid, no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P43005 View All» Entrez Gene Number: NM_004170.4 View All» Gene Symbol:
  • SLC1A1

  • EAAC1

  • EAAT3
    View All» Alternate Names: EAAC1; EAAT3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: SwissProt: P43005 # Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).SIZE: 524 amino acids; 57100 Da SUBUNIT: Interacts with ARL6IP5/PRAF3 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).PTM: Glycosylated.DISEASE: SwissProt: P43005 # Defects in SLC1A1 may be a cause of dicarboxylicamino aciduria [MIM:222730]; also known as glutamate-aspartate transport defect. This is as defect in renal and probably intestinal transport of glutamic and aspartic acids and is associated with moderate hyperprolinemia.SIMILARITY: SwissProt: P43005 ## Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Glutamate Transporter Antibody, neuronal | AB1520 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Target / Localization: Plasma Membrane View All» Format: Serum View All» Host: Goat View All»
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