货号：AB144P-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Choline Acetyltransferase Antibody | AB144P-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Choline acetyltransferase found in cholinergic neurons in brain and central nervous systems. View All» Molecular Weight: 70 kDa View All» Immunogen: Human placental enzyme. View All» Background Information: Acetylcholine (ACh) is a common neuro-transmitter for motoneurons, preganglionic autonomic neurons, postganglionic para-sympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker. View All» Species Reactivity:

• Mouse

• Rat

• Human

• Chicken

• Avian

• Guinea Pig

• Opossum
  View All» Species Reactivity Note: Rat, mouse, monkey, guinea pig, chicken, opossum, avian and human (western blot). View All» Application Notes: Immunohistochemistry: A previous lot of this antibody was used in immunohistochemistry at 1:100 dilution. See attached protocol.Optimal working dilutions must be determined by end user. View All» Control: Rat hypothalamus tissue. View All» Quality Assurance: Evaluated by Western Blot on NIH/3T3 lysates.Western Blot Analysis: 1:1000 dilution of this antibody detected ChAT on 10 µg of NIH/3T3 lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified goat polyclonal in buffer containing PBS containing 5 mg/mL BSA and 0.2% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt. For short term storage (3-4 weeks) maintain at +2-8°C. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P28329 View All» Entrez Gene Number: NP_065574 View All» Gene Symbol:
  • CHAT

  • ChAT

  • CHOACTase

  • CMS1A

  • CMS1A2
    View All» Alternate Names:
    • Choline acetylase

    • acetyl CoA:choline O-acetyltransferase

    • choline acetyltransferase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer disease. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq].Transcript Variant: This variant (M) contains alternate 5' exon M, uses an upstream start codon, and encodes isoform 2. View All» UniProt Summary: FUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.SIZE: 748 amino acids; 82568 Da DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Choline Acetyltransferase Antibody | AB144P-200UL View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Goat View All»
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