货号：AB10011

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Human TLR9 Antibody | AB10011 View All» Replaces: AB10011 is a recommended replacement for AB4219 and MAB10097. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes TLR9, isoform A (Toll-like Receptor 9), a member of the Toll-like receptor family, which plays a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The gene encoding TLR9 is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. View All» Immunogen: Fusion protein corresponding to amino acids 311-465 of human TLR9. View All» Isotype: IgY View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500-1:2,000 Optimal working dilutions must be determined by the end user. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein A purfied View All» Presentation: Liquid in PBS containing no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles View All» UniProt Number: Q9NR96 View All» Entrez Gene Number: NM_017442.2 View All» Gene Symbol:

• TLR9

• ORFNames=UNQ5798/PRO19605

• CD289
  View All» Alternate Names: Toll-like Receptor 9; CD289 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. View All» UniProt Summary: FUNCTION: SwissProt: Q9NR96 # Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.SIZE: 1032 amino acids; 115860 Da SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.SIMILARITY: SwissProt: Q9NR96 ## Belongs to the Toll-like receptor family. & Contains 26 LRR (leucine-rich) repeats. & Contains 1 TIR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Human TLR9 Antibody | AB10011 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Chicken View All»
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