金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Gly26-Ala95 Accession #:Q9NP10 N-terminal Sequence Analysis:Gly26 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level:< 1.0 EU per 1 μg of the protein by the LAL method. Predicted Molecular Mass:7.5 kDa Activity:Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.The ED₅₀ for this effect is typically 0.3 - 1.5 ng/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS. See Certificate of Analysis for details. Molecule Information: IGF-I Long Name: Insulin-like Growth Factor I Aliases: IGF1; IGF-1; Somatomedin A; Somatomedin C Entrez Gene IDs: 3479 (Human); 16000 (Mouse); 24482 (Rat) Background: IGF Ligands

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.