R&D Systems代理AF6665 Human NM23-H2 Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF6665 Human NM23-H2 Affinity Purified Polyclonal Ab (100 UG)

2025-07-22

货号：AF6665

品牌：R&D Systems

规格：100ug

目录价：￥4620.00

市场价格：￥3696.00

会员价格：￥3696.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NM23-H2 Long Name: Non-metastatic Protein 23 Homolog 2 Aliases: NDK B; NDP Kinase B2; NDPKB; NM23B; NME2 Entrez Gene IDs: 4831 (Human); 18103 (Mouse); 83782 (Rat) Background: NM23-H2

View NM23-H2 IHC images. NM23-H2 or NME-2 (non-metastatic cell 2; also Nucleoside diphosphate kinase B, nm23-H2/B, NDPK-B and PUF) is a 17-19 kDa class 1 member of the NME/NDPK family of molecules. It is widely expressed, found in both cytosol and nucleus, and participates in multiple activities. In conjunction with nm23-H1, NME-2 forms homo- and heterohexamers (three dimers or two trimers) that mediate the transfer of phosphate from ATP to nucleoside diphosphates. It also serves as a transcriptional regulator of genes such as c-myc and PDGF-A. Human NME-2 is 152 amino acids (aa) in length. It contains a kinase region (aa 5-134), two potential phosphorylation sites (Tyr52 and Thr94), a phosphohistidine residue at position 118, and multiple lysine acetylation sites. There is one potential NME-2 splice form that shows a six aa substitution for aa 77-152. The genes for NME-1 and NME-2 are adjacent, and an unusual splicing event generates a 33 kDa fusion protein (NM23-LV) that is composed of aa 1-114 of NME-1 plus a Thr insert that is N-terminally coupled to full-length NME-2. Full-length human NME-2 shares 88% and 98% aa identity with human NME-1 and mouse NME-2, respectively.

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