金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PLK1 Long Name: Polo-like Kinase 1 Aliases: STPK13 Entrez Gene IDs: 5347 (Human); 18817 (Mouse); 25515 (Rat) Background: PLK1 PLK1 is a member of the Polo-Like Kinase family that localizes to centrosomes or spindle pole bodies and undergoes dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics. PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death.