货号：14-115

品牌：Merck Millipore

规格：

目录价：￥4200.00

市场价格：￥3570.00

会员价格：￥3360.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PKC, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 µg View All» Product Overview: phosphorylation site motifs (Arg/Lys1-3,X2-0)-Ser/Thr(X2-0,Arg/Lys1-3) > Ser/Thr-(X2-0,Arg/Lys1-3) >(Arg/Lys1-3,X2-0)-Ser/Thr, where X is any amino acid.2PKC Lipid activator (Catalog # 20-133) is required for use. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. View All» UniProt Summary: FUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).SIZE: 672 amino acids; 76764 Da SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain. View All» Species: Rat View All» Brand Family: Upstate View All» Source: rat brain View All» Protein Target: PKC View All» Storage Conditions: 6 months at -70 C View All» Target Sub-Family: AGC View All» Gene Symbol:

• PRKCA

• PKC-A

• PKCA

• MGC129901

• AAG6

• MGC129900

• PRKACA

• PKC-alpha
  View All» Product Name: PKC, active View All» Quality Assurance: routinely evaluated by kinase assay View All» UniProt Number:
  • P17252

  • P05771

  • P05129
    View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_002737.2 View All» Purification Method: Sequential chromatography of an EGTA extract of Ca2+-washed brain particulate fraction on DEAE-Sephacel, phenyl-Sepharose™ and poly-L-lysine-agarose. View All»
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