金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Gln18-Lys359 Accession #:NP_110402 N-terminal Sequence Analysis:Gln18 predicted: No results obtained, sequencing might be blocked Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:38.5 kDa SDS-PAGE:45 kDa, reducing conditions Activity:Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells.The ED₅₀ for this effect is typically 0.03-0.15 µg/mL, in the presence of 5 ng/mL of Recombinant Mouse Wnt‑3a (Catalog# 1324-WN).Optimal dilutions should be determined by each laboratory for each application. Molecule Information: Wnt-5b Long Name: Wingless-type MMTV Integration Site Family, Member 5b Entrez Gene IDs: 81029 (Human) Background: Wnt-5b

Wnt-5b is a 49 kDa glycoprotein of the subgroup of Wnts that is implicated in the non-canonical Wnt/Ca²⁺ pathway. Wnt-5b is not axis-inducing in Xenopus embryos and only weakly transforms C57MG mammary epithelial cells. In adult mice, Wnt-5b is expressed in heart, liver, brain, lung, testes, kidney, and pancreas. Wnt-5b appears to promote adipogenesis and is upregulated in early adipogenesis. Also, Wnt-5b overexpression in 3T3-L1 cells partially inhibits canonical Wnt suppression of adipogenesis.

Human Wnt-5b polymorphisms have been associated with Type II diabetes. Although Wnt-5a and Wnt-5b share 83% amino acid identity, they show differential expression and regulation of cyclin D1 and p130 during endochondral bone development. Together, Wnt-5a and Wnt-5b appear to coordinate chondrocyte proliferation and differentiation. The expression of Wnt-5a and Wnt-5b are also implicated in limb development. Mature mouse Wnt-5b shows 94%, 98%, 90% and 88% amino acid identity with mature human, rat, chick and Xenopus Wnt-5b, respectively.