货号：12-457

品牌：Merck Millipore

规格：100Ug

目录价：￥3909.00

市场价格：￥3322.65

会员价格：￥3127.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MYPT1 (654-880) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: ROK substrate protein corresponding to amino acids 654-880 of human MYPT1 with an N-terminal GST tag. MW = 60 kDa. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. View All» UniProt Summary: FUNCTION: SwissProt: O14974 # Regulates myosin phosphatase activity.SIZE: 1030 amino acids; 115281 Da SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16.SUBCELLULAR LOCATION: Cytoplasm. Note=Along actomyosin filaments and stress fibers.PTM: Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: O14974 ## Contains 6 ANK repeats. View All» Quality Assurance: Routinely evaluated as a substrate in a Protein Kinase Assay. View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Presentation: 100mM Tris-HCl pH 8.0, 200mM NaCl, 10mM glutathione and 5μg/ml leupeptin. Frozen solution. View All» UniProt Number: O14974 View All» Storage Conditions: 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery, centrifuge the vial prior to removing the cap. View All» Gene Symbol:

• PPP1R12A

• MYPT1

• MGC133042

• MBS
  View All» Product Name: MYPT1 (654-880) View All» Entrez Gene Number: NM_002480.1 View All» Purity: ≥70% as judged by SDS PAGE and Coomassie staining. View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：http://16ao.com/thread-137316.htm
  © Merck Millipore代理12-457 MYPT1 (654-880);store at -20℃，产品报价联系微信jinshanbio