R&D Systems代理5768-GT-020 Recombinant Human Fucosyltransferase 8/FUT8 Protein, CF (20 UG)-试剂-金山科研平台

R&D Systems代理5768-GT-020 Recombinant Human Fucosyltransferase 8/FUT8 Protein, CF (20 UG)

2025-07-24

货号：5768-GT-020

品牌：R&D Systems

规格：20ug

目录价：￥4900.00

市场价格：￥3920.00

会员价格：￥3920.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Asp32-Lys575, with an N-terminal human CD33 signal sequence, and 6-His tag Accession #:Q9BYC5 N-terminal Sequence Analysis:His Purity:>90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. Endotoxin Level: Predicted Molecular Mass:64 kDa SDS-PAGE:58-62kDa, reducing conditions Activity:Measured by its ability to hydrolyze the donor substrate GDP-fucose.The specific activity is >0.75 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris and NaCl.See Certificate of Analysis for details. Molecule Information: Fucosyltransferase 8/FUT8 Aliases: alpha1-6FucT; FUT8 Entrez Gene IDs: 2530 (Human); 53618 (Mouse); 432392 (Rat) Background: Fucosyltransferase 8

View FUT8 IHC images. N-glycans, O-glycans and glycolipids are frequently fucosylated at terminal sites. Therefore, fucose is often part of a sugar epitope with an important biological function. Well-known fucose-containing glycans include Lewis and ABO blood group antigens. Lewis epitopes are key elements involved in leukocyte homing and extravasation and thus are important for lymphocyte maturation and natural defense functions. Fucose-containing glycans also play critical roles in cell signaling and development. More than 10 fucosyltransferases have been cloned and all of them are Golgi-resident type II membrane proteins. FUT1 and FUT2 are alpha (1-2) fucosyltransferases and are responsible for ABO blood-group antigen synthesis. FUT3, FUT4, FUT5, FUT6, FUT7 and FUT9 are alpha (1-3) or alpha (1-4) fucosyltransferases and are responsible for Lewis antigen generation . FUT8 is the only alpha (1,6) fucosyltransferase that adds a fucose to the chitobiose core of N-glycans. The alpha 1,6-fucosylation of N-glycan in human IgG1 was reported to suppress antibody-dependent cellular cytotoxicity. Disruption of the FUT8 gene induced severe growth retardation, emphysema, and death during postnatal development in mice. The absence of alpha 1,6-fucosylation on transforming growth factor-beta 1 (TGF-beta 1) receptors was found to be involved in the mouse phenotypes. The activity of this enzyme has been measured using a phosphatase-coupled assay.

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