货号：09-821

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Krüeppel-like factor 4 (Klf4) Antibody | 09-821 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Klf4 at the N-terminus. View All» Molecular Weight: ~55 kDa observed View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of mouse Klf4. View All» Background Information: Krüppel-like factors (KLFs) are zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. Krüppel-like factor 4 (Klf4) has diverse functionss and acts as both an activator and repressor of transcription. The Klf protein has been shown to activate its own transcription throught its interaction with CACCC core sequences. High expression of Klf4 is observed in differentiating layers of epidermis and a loss of expression results in a break-down of barrier function including protection against pathogen invasion and dehydration. KLF4 is also associated with other biological functions such as proliferation, differentiation and carcinogenesis in gastrointestinal tissues. After DNA damage, Klf4 has been shown to induce DNA repair pathways. Klf4 seems to hinder prostate cancer tumor cell growth and migration. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse and human. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Klf4 in NIH/3T3, A431, and HeLa cells. View All» Control: Mouse embryonic stem cell chromatin extract View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell chromatin extract.Western Blot Analysis: 1:500 dilution of this antibody detected Klf4 on 10 µg of mouse embryonic stem cell chromatin extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q60793 View All» Entrez Gene Number: NP_034767.2 View All» Gene Symbol:
  • KLF4

  • EZF

  • GKLF
    View All» Alternate Names:
    • Kruppel-like factor 4 (gut)

    • Gut-enriched krueppel-like factor

    • endothelial Kruppel-like zinc finger protein

    • Krueppel-like factor 4

    • Epithelial zinc finger protein EZF

    • Krüppel-like factor

    • klf
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. SUBUNIT STRUCTURE: Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription (By similarity).SUBCELLULAR LOCATION: NucleusTISSUE SPECIFICTY: Highest expression in the colon. Lower levels in testis, lung and small intestine.INDUCTION: By interferon-gamma in Stat1-dependent manner. DISRUPTION: phenotype Death shortly after birth due to loss of epidermal barrier function resulting from perturbation of late-stage epidermal differentiation structures including the cornified envelope. When selectively deleted in the surface ectoderm-derived structures of the eye, embryos develop normally and adults are viable and fertile but mutants display down-regulation of Krt12 and Aqp5 and multiple ocular defects including corneal epithelial fragility, stromal edema, defective lens and loss of conjunctival goblet cells. Ref.9 Ref.10SEQUENCE SIMILARITIES: Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 3 C2H2-type zinc fingers.SEQUENCE CAUTION: The sequence AAC52939.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH10301.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Krüeppel-like factor 4 (Klf4) Antibody (09-821) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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