货号：09-089

品牌：Merck Millipore

规格：

目录价：￥3475.00

市场价格：￥2953.75

会员价格：￥2780.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Notch 4 Antibody | 09-089 View All» Replaces: 07-018 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Detects Notch 4 View All» Molecular Weight: 56 kDa View All» Epitope: Intracellular Domain View All» Immunogen: GST-coupled recombinant protein corresponding to amino acids 1796-1964 of Notch 4. View All» Background Information: The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Rat and Mouse. View All» Quality Assurance: Evaluated by western blot on human placenta cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect Notch 4 in human placenta cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Antigen affinity purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q99466 View All» Entrez Gene Number: NM_004557 View All» Gene Symbol:
  • FLJ16302

  • INT3

  • MGC74442

  • NOTCH3

  • OTTHUMP00000062678

  • hNotch4

  • notch4
    View All» Alternate Names:
    • Notch (Drosophila) homolog 4

    • Notch 4

    • Notch homolog 4 (Drosophila)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system By similarity.SUBUNIT STRUCTURE: Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds By similarity. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Notch 4 intracellular domain: Nucleus. Note= Following proteolytical processing NICD is translocated to the nucleus.TISSUE SPECIFICITY: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.PTM: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane By similarity.Phosphorylated By similarity.POLYMORPHISM: The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).SEQUENCE SIMILARITIES: Belongs to the NOTCH family.Contains 5 ANK repeats.Contains 28 EGF-like domains.Contains 3 LNR (Lin/Notch) repeats.SEQUENCE CAUTION: The sequence BAA09708.1 differs from that shown. Reason: Frameshift at positions 1438 and 1463. View All» Product Name: Anti-Notch 4 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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