货号：07-938

品牌：Merck Millipore

规格：100Ug

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HNF-3A/ FOXA1 Antibody | 07-938 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HNF-3A/FOXA1. View All» Molecular Weight: ~ 51 kDa View All» Epitope: Entire protein View All» Immunogen: Recombinant protein corresponding to the entire protein of human HNF-3A/FOXA1. View All» Background Information: HNF-3A, Hepatocyte nuclear factor 3-alpha (also called FOXA1) is member of the Forkhead family of winged-helix transcription factors. This protein family has around 50 known transcription factors and play an important role in the regulation of cell differentiation, organogenesis, and gene expression. High levels of expression of HNF-3A has been observed in tumors arising from both the prostate and breast. Here it is believed this protein interacts with the androgen receptor in prostate tumors and the estrogen receptor α in breast tumors. In the case of ERα, HNF-3A interacts with cis-regulatory regions in heterochromatin and enhances the interaction of ERα with chromatin. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Homology to Chimpanzee is 96%. Homology to canine is 94%. View All» Application Notes: Western Blot (SNAP ID) Analysis: 1 µg/ml from a representative lot detected HNF-3A/FOXA1 on 10 µg of human pancreas tissue lysate.Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected HNF-3A/FOXA1 in NIH/3T3 and HeLa cells. View All» Control: Human pancreas tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human pancreas tissue lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected HNF-3A/FOXA1 on 10 µg of human pancreas tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55317 View All» Entrez Gene Number: NP_004487 View All» Gene Symbol:
  • FOXA1

  • HNF-3-alpha

  • HNF-3A

  • HNF3A

  • TCF3A

  • MGC33105
    View All» Alternate Names:
    • Forkhead box protein A1

    • forkhead box A1

    • hepatocyte nuclear factor 3, alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-HNF-3A/ FOXA1 Antibody (07-938) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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