金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ala23-Leu349, with a C-terminal 6-His tag Accession #:P34015 N-terminal Sequence Analysis:Ala23 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:36.5 kDa (monomer) SDS-PAGE:55- 60 kDa, reducing conditions Activity:Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Gileva, I.P. et al. (2006) Biochim. Biophys. Acta. 1764:1710.The ED₅₀ for this effect, in the presence of 0.25 ng/mL of rhTNF-alpha, is typically 0.6 - 2.4 ng/mL. Molecule Information: CRMB Long Name: Cytokine Response-modifying Protein B Aliases: G2R; G4R Background: CRMB CRMB is one of several cytokine response modifiers encoded by poxviruses such as variola (the causative agent of human smallpox). It has an N-terminal domain that binds TNF and lymphotoxin alpha and a C-terminal domain that binds several chemokines. CRM proteins shield poxviruses from proinflammatory and antiviral immune responses.