货号：07-705

品牌：Merck Millipore

规格：

目录价：￥4633.00

市场价格：￥3938.05

会员价格：￥3706.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LSD1/BHC110 Antibody | 07-705 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes BHC110/LSD1 View All» Molecular Weight: 110kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 47-66 (PAEV-GPGAVGERTPRKKEPP) of human BRAF-HDAC complex protein/Lysine-specific histone demethylase 1 (BHC110/LSD1). View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: O60341 View All» Entrez Gene Number: NM_015013.2 View All» Gene Symbol:

• AOF2

• LSD1

• KIAA0601

• BHC110
  View All» Alternate Names: KDM1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternate splicing has been observed; however, not all transcript variants have been fully characterized. View All» UniProt Summary: FUNCTION: SwissProt: O60341 # Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri- methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys- 9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.COFACTOR: FAD.SIZE: 852 amino acids; 92903 Da SUBUNIT: Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR).SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitously expressed.DOMAIN: SwissProt: O60341 The SWIRN domain may act as an anchor site for a histone tail.SIMILARITY: Belongs to the flavin monoamine oxidase family. & Contains 1 SWIRM domain. View All» Brand Family: Upstate View All» Product Name: Anti-LSD1/BHC110 Antibody | 07-705 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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