货号：07-694

品牌：Merck Millipore

规格：200Ug

目录价：￥3697.00

市场价格：￥3142.45

会员价格：￥2957.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LKB1 Antibody | 07-694 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes LKB1. View All» Molecular Weight: Mr 51 kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 359-373 (KIEDGIIYTQDFTVPG- K) of mouse LKB1 with N and C-terminal K residues added for conjugation purposes View All» Isotype: IgG View All» Species Reactivity: Rat View All» Species Reactivity Note: Predicted to cross-react with mouse and human based on sequence homology View All» Control: Rat2 cell lysate View All» Quality Assurance: routinely evaluated by immunoblot on Rat2 cell lysates View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q15831 View All» Entrez Gene Number: NM_000455.4 View All» Gene Symbol:

• STK11

• LKB1

• PJS
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.COFACTOR: Magnesium or Manganese.SIZE: 433 amino acids; 48636 Da SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-LKB1 Antibody | 07-694 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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