货号：07-158

品牌：Merck Millipore

规格：

目录价：￥3853.00

市场价格：￥3275.05

会员价格：￥3082.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-KDR/Flk-1/VEGFR2 | 07-158 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes KDR/Flk-1/VEGFR2 at the cytoplasmic domain. View All» Molecular Weight: ~150/180 kDa observed. 180 kDa is the mature form and 150 kDa is the immature unmodified form. In human and mouse cells the mature form of VEGFR2 is ~220-225 kDa. Faint band at ~225 kDa may be endogenous VEGFR2 in PAE cells. View All» Epitope: Cytoplasmic domain View All» Immunogen: GST-tagged recombinant protein corresponding to mouse KDR/Flk-1/VEGFR2 at the cytoplasmic domain. View All» Background Information: The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines. The VEGF receptors stimulate the Ras-MAP kinase pathway, suggesting that it signals as a conventional receptor tyrosine kinase. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. Expected to react with Rat based on a 99% sequence homology and Human based on 92% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:100 dilution from a representative lot detected KDR/Flk-1/VEGFR2 in mouse embryo vascular endothelium tissue. View All» Control: PAE cells transfected with CSF/VEGFR2 chimera and treated with CSF View All» Quality Assurance: Evaluated by Western Blot in PAE cells transfected with CSF/VEGFR2 chimera and treated with CSF.Western Blot Analysis: 1:1,000 dilution of this antibody detected KDR/Flk-1/VEGFR2 on 10 µg of PAE cells transfected with CSF/VEGFR2 chimera and treated with CSF. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35968 View All» Entrez Gene Number: NP_002244 View All» Gene Symbol:

• KDR

• VEGFR-2

• VEGFR2

• FLK1

• VEGFR

• CD309
  View All» Alternate Names:
  • Vascular endothelial growth factor receptor 2

  • VEGFR-2

  • Fetal liver kinase 1

  • FLK-1

  • Kinase insert domain receptor

  • Protein-tyrosine kinase receptor flk-1

  • CD309
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SIZE: 1356 amino acids; 151527 Da SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-KDR/Flk-1/VEGFR2 | 07-158 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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