货号：07-1481

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRAK-M Antibody, a.a. 581-596 | 07-1481 View All» Replaces: 07-1481 is a recommended replacement for AB16534 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IRAK-M at a.a. 581-596. View All» Molecular Weight: ~68 kDa View All» Epitope: a.a. 581-596 View All» Immunogen: Rabbit anti-IRAK-M polyclonal antibody was raised against a peptide corresponding to amino acids 581 to 596 of human IRAK-M (3). View All» Isotype: IgG View All» Background Information: IRAK (IL-1 receptor associated kinase) is a serine/threonine kinase which associates with the IL-1 receptor after ligand binding to initiate a signaling cascade that ultimately results in nuclear localization of NFκB thought to be important for inflammation. Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF- κB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-κB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1and LPS. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat reactive. View All» Application Notes: Optimal working dilutions must be determined by end user.Immunohistochemistry(paraffin):Representative images from a previous lot.Optimal Staining of IRAKm With Citrate pH 6.0 Epitope Retrieval: Human KidneyWestern blot: 0.5 to 1.0 µg/mL of a previous lot was used on mouse spleen or rat kidney tissue lysate can be used as positive control and a 68 kDa major band can be detected. View All» Control: A431 Cell Lysate, mouse spleen or rat kidney tissue lysate View All» Quality Assurance: Routinely evaluated by Western Blot on A431 lysates.Western Blot Analysis: 1:500 dilution of this lot detected IRAK on 10 μg of A431 lysates. View All» Purification Method: Purified View All» Presentation: Purified rabbit polyclonal IgG in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 1 year from date of receipt."Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9Y616 View All» Entrez Gene Number: NM_007199.1 View All» Gene Symbol:
  • IRAK3

  • IRAK-3

  • IRAKM

  • ASRT5

  • IRAK-M

  • EC 2.7.11.1
    View All» Alternate Names:
    • IL- 1 receptor-associated kinase M

    • Interleukin-1 receptor-associated kinase 3

    • Interleukin-1 receptor-associated kinase M
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. TISSUE SPECIFICITY: Expressed predominantly in peripheral blood lymphocytes. DISEASE: Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 protein kinase domain. CAUTION: Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in Ref.1, while other authors describe this as an inactive kinase. View All» Product Name: Anti-IRAK-M Antibody, a.a. 581-596 | 07-1481 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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