货号：07-1448

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-WAVE-1 Antibody | 07-1448 View All» Replaces: AB4095 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes an internal amino acid sequence of WAVE-1. View All» Molecular Weight: Approx. 62 kDa View All» Immunogen: Synthetic peptide corresponding to an internal amino acid sequence of human WAVE1. Immunogen sequence is conserved in rat and mouse. View All» Background Information: Recognizes WAVE1 (Wiskott-Aldrich syndrome protein family member 1, WASP-family protein member 1). WAVE1 is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WAVE1 binds actin and ARP2/3 complex. It binds the ARP2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with mouse and human. Reactivity with other species has not been determined. View All» Control: RAW264.7 cell lysat View All» Quality Assurance: Evaluated by Western Blot in RAW264.7 cell lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected WAVE-1 on 10 µg of RAW264.7 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2 -8ºC in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: Q92558 View All» Entrez Gene Number: NP_003922.1 View All» Gene Symbol:
  • KIAA0269

  • OTTHUMP00000016990

  • SCAR1

  • WAVE

  • WAVE1

  • FLJ31482
    View All» Alternate Names:
    • Protein WAVE-1

    • Verprolin homology domain-containing protein 1

    • WAS protein family, member 1

    • WASP family protein member 1

    • Wiskott-Aldrich syndrome protein family member 1

    • homology of dictyostelium scar 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.SUBUNIT STRUCTURE: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 By similarity. Binds actin and the Arp2/3 complex. Interacts with BAIAP2.SUBCELLULAR LOCATIION: Cytoplasm › cytoskeleton. Note: Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.TISSUE SPECIFICITY: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.DOMAIN: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.SEQUENCE SIMILARITIES: Belongs to the SCAR/WAVE family.Contains 1 WH2 domain. View All» Product Name: Anti-WAVE-1 View All» Concentration: 1.82 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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