货号：07-1221

品牌：Merck Millipore

规格：100Ug

目录价：￥4771.00

市场价格：￥4055.35

会员价格：￥3816.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PP2A-B’ (B56) Antibody | 07-1221 View All» Replaces: 07-1221 is a recommended replacement for AB4088 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody is specific to PP2A-B’ subunits. View All» Molecular Weight: ~56 kDa View All» Epitope: Internal View All» Immunogen: The immunogen used for the purified peptide conjugated to KLH corresponds to the sequence NH2-Val-Ser-Ser-Pro-His-Phe-Gln-Val-Ala-Glu- Arg-Ala-Leu-Tyr-COOH. View All» Isotype: IgG View All» Background Information: PP2A is a heterotrimeric type 2 Ser/Thr phosphatase, composed of a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B'/PR61, and B''/PR72 . The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variants derived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. PTPA is a member of the B' family that is required for activation of PP2A by an undefined mechanism. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Bovine, Human, Mouse, Rat. View All» Control: HeLa Cell Lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HeLa lysates.Western Blot Analysis: 1:500-1:1,500 dilution of this antibody detected PP2A-B' (B56) in 10 μg of multiple cell lysates. View All» Purification Method: Purified View All» Presentation: Purified rabbit polyclonal IgG in PBS with 0.08% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q15257 View All» Entrez Gene Number: NM_006243 View All» Gene Symbol:
  • MGC2184

  • OTTHUMP00000022333

  • PP2A

  • PR53

  • PTPA
    View All» Alternate Names:
    • PP2A phosphatase activator

    • PP2A, subunit B'

    • PP2A, subunit B', PR53 isoform

    • Phosphotyrosyl phosphatase activator

    • protein phosphatase 2A activator, regulatory subunit 4

    • protein phosphatase 2A, regulatory subunit B'

    • protein phosphatase 2A, regulatory subunit B' (PR 53)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. View All» UniProt Summary: FUNCTION: Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer in presence of ATP and Mg2+ (in vitro).SUBUNIT STRUCTURE:Associates with PP2A heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). TISUE SPECIFICITY: Widely expressed.SEQUENCE SIMILARITY: Belongs to the PTPA-type PPIase family. View All» Product Name: Anti-PP2A-B’ (B56) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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