货号：MABS194

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-K-Ras Antibody, clone 234-4.2 | MABS194 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~22 kDa observed View All» Immunogen: Recombinant protein corresponding to rat c-K-Ras. View All» Clone: 234-4.2 View All» Isotype: IgG2aκ View All» Background Information: GTPase KRas (c-k-ras; K-ras) is a membrane-bound G protein belonging to the family of Ras GTPases. They are activated by the binding of GTP in response to signals from various receptors including the epidermal growth factor receptor (EGFR). Ras GTPases are regulated by guanine nucleotide exchange factors (GEF) and GTPase activating proteins (GAP) and lie upstream of the MAP kinase pathway which controls a range of cellular processes including proliferation and differentiation. Previous studies have suggested that KRas plays an important role in embryonic development, and it may also contribute to the pathogenesis of colorectal cancer via an EGFR-mediated pathway. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat based on immunogen design. View All» Application Notes: Western Blot Analysis: A representative lot detected c-K-Ras in A431 cell lysate.Western Blot Analysis: A representative lot from an independent laboratory detected c-K-Ras in primary humanlymphoid leukemia cell lysates, and in normal and HA-dynamin K44A mutant HeLa cell lysates (Omerovic, J., et al. (2008). Oncogene. 27(19):2754-2762.).Immunohistochemistry Analysis: A representative lot from an independent laboratory detected c-K-Ras in non-small cell lung cancer cells (Volm, M., et al. (2002). Clin Cancer Res. 8(6):1843-1848.). View All» Control: SW-480 cell lysate View All» Quality Assurance: Evaluated by Western Blot in SW-480 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected c-K-Ras in 10 µg of SW-480 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P08644 View All» Entrez Gene Number: NP_113703 View All» Gene Symbol:

• Kras

• Kras2
  View All» Alternate Names:
  • GTPase Kras

  • K-Ras 2

  • Ki-Ras

  • c-K-ras

  • c-Ki-ras
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: An oncogene and member of the small GTPase superfamily. View All» UniProt Summary: FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).SUBUNIT STRUCTURE: Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family. View All» Product Name: Anti-c-K-Ras, clone 234-4.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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