货号：MABS18

品牌：Merck Millipore

规格：100MIG

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1 | MABS18 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~39 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human Aldose reductase.Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program. View All» Clone: CPTC-AKR1B1-1 View All» Isotype: IgG1κ View All» Background Information: Aldose reductase (AR) is s a therapeutic target for treatment of long-term obstacles of diabetes. AR has also been shown to be a component of antioxidant defense and of stress-induced signaling. It is an important component of cellular redox state and regulation of signaling cascades that may play a part in regulating cytotoxic occurrences. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.) View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 0.001 µg/mL of this antibody detected Aldose reductase on 10 µg of human kidney tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15121 View All» Entrez Gene Number: NP_001619 View All» Gene Symbol:

• AR

• ALDR1

• ADR

• ALR2
  View All» Alternate Names:
  • aldo-keto reductase family 1, member B1 (aldose reductase)

  • aldose reductase

  • Aldo-keto reductase family 1 member B1

  • low Km aldose reductase

  • Lii5-2 CTCL tumor antigen

  • aldehyde reductase 1

  • Aldehyde reductase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.CATALYTIC ACTIVITY: Alditol + NAD(P)+ = aldose + NAD(P)H.ENZYME REGULATION: Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis. SUBUNIT STRUCTURE: Monomer.SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. SEQUENCE SIMILARITIES: Belongs to the aldo/keto reductase family. View All» Product Name: Anti-Aldose reductase, clone CPTC-AKR1B1-1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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