货号：MABE204

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HoxB4 Antibody, clone EP1919Y, Rabbit | MABE204 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the middle region of HoxB4. View All» Molecular Weight: ~34 kDa observed View All» Epitope: Middle region View All» Immunogen: Synthetic peptide corresponding to the middle region of human HoxB4. View All» Clone: EP1919Y View All» Isotype: IgG View All» Background Information: Homebox transcription factors (Hox) are encoded by highly conserved developmental genes that are involved embryonic and early hematopoietic development. Specifically, Homeobox B4 (HoxB4) is a transcription factor encoded by HOXB4 gene and it is involved in the developmental regulation of specific positional identities on the anterior-posterior axis of cells. Like all members of HOX family, HoXB4 is abundantly expressed in primitive hematopoietic stem cell (HSC), but then decline with lineage-specific terminal differentiation (1). In HSC, stem cell self-renewal activity is regulated by USF1/2 binding to HoxB4, where binding possibly favors stem cell self-renewal instead of cell differentiation. Jun-B and Fra-1 has been linked as key mediators during cell proliferation and differentiation induced by HoxB4, which leads to increase expression of Cyclin D1 and G1 shortening (2). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunocytochemistry Analysis: 1:100-1:250 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: 1:40 dilution from a representative lot was used in IP.Flow Cytometry Analysis: 1:20 dilution from a representative lot was used in FC.Immunohistochemistry Analysis: 1:100-1:250 dilution from a representative lot detected HoxB4 in human placenta tissue. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 1:500 dilution of this antibody detected HoxB4 in K562 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below-20°C may cause glycerol containing Solutions to become frozen during storage. View All» UniProt Number: P17483 View All» Gene Symbol:

• HOX2F

• HOX-2.6

• HOX2
  View All» Alternate Names:
  • homeobox B4

  • homeo box B4

  • Homeobox protein Hox-2.6

  • Homeobox protein Hox-2F

  • homeobox protein Hox-B4

  • homeo box 2F
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Flow Cytometry

    • Immunoprecipitation

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9 weeks from conception.SEQUENCE SIMILARITIES: Belongs to the Antp homeobox family. Deformed subfamily.Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-HoxB4, clone EP1919Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Diluted Culture Supernatant View All» Host: Rabbit View All»
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