货号：05-1135

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDGFR Antibody, clone CH-3 | 05-1135 View All» Replaces: 05-1135 is a recommended replacement for MAB3091 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 211 amino acids; 24043 Da View All» Immunogen: Recombinant Platelet-Derived Growth Factor Receptor View All» Clone: CH-3 View All» Isotype: IgG1 View All» Background Information: PDGFR (Platelet-Derived Growth Factor Receptor) is a receptor tyrosine kinase for the PDGF family of growth factors. PDGF homo and hetero- dimmers (dimer of A (17 kDa) and B (14 kDa) chains (AA, AB, or BB)) bind to the two structurally related a and b PDGF Receptors (PDGFRa and PDGFRb). The type A PDGF Receptor binds all three PDGFs with high affinity, whereas the type B PDGF Receptor is selective for PDGF-BB. This binding results in the dimerization of the receptor and the subsequent kinase activation of the receptor tyrosine kinase (RTK) and its autophosphorylation. These phosphorylations allow for various proteins, such as PI3 Kinase, PLCg, and Grb2, to bind through their SH2 domains and transduce signals into the cell. The activation of PDGFFR triggers the intracellular loop and activates Ras, Erk1/2, and ROS. PDGFb has been implicated in embryonic development, angiogenesis, and development of tumors of glial origin. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and mouse. Expected to react with rat based on sequence homology. View All» Application Notes: ELISA: A previous lot of this antibody was used in ELISA.Immunohistochemistry(paraffin): Representative images from a previous lot.Optimal Staining of PDGF-A With Citrate pH 6.0 Epitope Retrieval: Rat Brain View All» Control: Jurkat cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on Jurkat lysates.Western Blot Analysis: 1:500 dilution of this lot detected PDGFR on 10 μg of Jurkat lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing 20 mM sodium phosphate, 250 mM NaCl, 0.1% NaN3, pH. 7.6 View All» Storage Conditions: Maintain at + 2-8 ° C in undiluted aliquots for up to 1 year from date of receipt. View All» UniProt Number: P09619 View All» Alternate Names:
  • Platelet Derived Growth Factor Receptor Beta

  • PDGF-R-beta

  • PDGFR-beta

  • Beta platelet-derived growth factor receptor

  • Beta-type platelet-derived growth factor receptor

  • CD140 antigen-like family member B

  • Platelet-derived growth factor receptor 1

  • PDGFR-1

  • CD140b
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA

    • Immunohistochemistry (Paraffin)
      View All» Product Name: Anti-PDGFR Antibody, clone CH-3 | 05-1135 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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