货号：MAB5416

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glutamate Receptor 3 Antibody, clone 3B3 | MAB5416 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Glutamate Receptor 3 (GluR3). No cross reactivity with GluR2. View All» Molecular Weight: ~ 110 kDa View All» Epitope: N-terminus View All» Immunogen: Fusion protein, N-terminus of GluR3 View All» Clone: clone 3B3 View All» Isotype: IgG1κ View All» Background Information: AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition.There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. Millipore’s anti-GluR2/3 antibody is useful for localizing expression of GluR2/GluR3 receptor assemblies in the PSD. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Monkey
  View All» Species Reactivity Note: Human, mouse and monkey. Expected to react with rat based on sequence homology. View All» Application Notes: Immunohistochemistry: A previous lot of this antibody was used in IH.Optimal working dilutions must be determined by end user. View All» Control:
  • Brain

  • Hippocampal tissue
    View All» Quality Assurance: Western Blot Analysis: A previous lot of this antibody was used in WB. View All» Purification Method: Protein A purfied View All» Presentation: Liquid in PBS. Contains no preservative. View All» Storage Conditions: Stable for 1 year at from date of receipt. View All» UniProt Number: P42263 View All» Entrez Gene Number: NM_000840.2 View All» Gene Symbol:
    • GLUR3

    • GluR3

    • GLURC

    • GRIA3
      View All» Alternate Names:
      • AMPA-selective glutamate receptor 3

      • Glutamate receptor ionotropic, AMPA 3

      • glutamate receptor 3

      • glutamate receptor C

      • glutamate receptor subunit 3

      • glutamate receptor, ionotrophic, AMPA 3
        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • Western Blotting

        • Immunocytochemistry

        • Immunohistochemistry

        • Immunohistochemistry (Paraffin)
          View All» Entrez Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. View All» UniProt Summary: FUNCTION: SwissProt:P42263 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.SIZE: 894 amino acids; 101,157 Da SUBUNIT:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with PRKCABP, GRIP1 and GRIP2.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.DISEASE INVOLVEMENT: Defects in GRIA3 are the cause of mental retardation X-linked type 94 (MRX94) [MIM:300699]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia.SIMILARITY: SwissProt: P42263 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Glutamate Receptor 3 Antibody, clone 3B3 | MAB5416 View All» Concentration: 0.77 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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