货号：04-592

品牌：Merck Millipore

规格：

目录价：￥4668.00

市场价格：￥3967.80

会员价格：￥3734.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Flotillin-1 Antibody, Rabbit, clone EP446Y | 04-592 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse Flotillin-1. View All» Immunogen: A synthetic peptide corresponding to residues in human Flotillin-1. View All» Clone: EP446Y View All» Background Information: Flotillin-1, also known as Reggie-2, belongs to a larger family of proteins that share an evolutionarily conserved stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (1). Flotillin-1 is a lipid raft-associated protein that has been implicated in various cellular processes. Flotillin was first found in cells that lack morphologically definable caveolae, as well as in non-caveolar membranes (2) and was subsequently identified in low density detergent-insoluble complexes of endothelial cells, where they were termed flotillins (3). As well as its postulated role in neuronal regeneration, flotilllin-1 has been implicated in insulin signaling to trigger glucose transporter redistribution in adipocytes (4) Flotillin also associates with phagosomes in macrophages (5). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse (positive control: K562 cell lysate) View All» Application Notes: WB: 1:500 View All» Purification Method: Protein A purfied View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: O75955 View All» Entrez Gene Number: NM_005803.2 View All» Gene Symbol:
  • FLOT1

  • Flotillin-1.
    View All» Alternate Names: Reggie-2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: O75955 # May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.SIZE: 427 amino acids; 47355 Da SUBUNIT: Hetero-oligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity).SUBCELLULAR LOCATION: Cell membrane, caveola; Peripheral membrane protein. Melanosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SIMILARITY: SwissProt: O75955 ## Belongs to the band 7/mec-2 family. Flotillin subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Flotillin-1 Antibody, Rabbit, clone EP446Y | 04-592 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Presynaptic View All» Format: Purified View All» Host: Rabbit View All»
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