货号：04-1507

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD265/RANK Antibody, clone R12-31 | 04-1507 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CD265/RANK. View All» Molecular Weight: ~ 67 kDa View All» Epitope: Unknown View All» Immunogen: Mouse CD265/RANK-transfected 2PK3 cells. View All» Clone: R12-31 View All» Isotype: IgG2aκ View All» Background Information: CD265 or RANK (Receptor Activator of Nuclear Factor κ B, also known as Tumor Necrosis Factor Receptor Superfamily, member 11a or TRANCE Receptor) is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK interacts with various TRAF family proteins and induces the activation of NF-kappa B and MAPK8/JNK. RANK is also expressed on dendritic cells and facilitates immune signaling. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Proven to react with mouse. View All» Application Notes: Flow Cytometry Analysis: 5 µg from a previous lot detected CD265/RANK in RAW264 macrophage cells. View All» Control: RAW264 macrophage cells View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O35305 View All» Entrez Gene Number: NP_033425.3 View All» Gene Symbol:

• TNFRSF11A

• RANK

• OFE

• ODFR

• CD265

• TRANCER
  View All» Alternate Names:
  • CD265 antigen

  • Osteoclast differentiation factor receptor

  • Receptor activator of NF-KB

  • loss of heterozygosity, 18, chromosomal region 1

  • receptor activator of nuclear factor-kappa B

  • tumor necrosis factor receptor superfamily, member 11a

  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator

  • tumor necrosis factor receptor superfamily, member 11a,activator of NFKB
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. SUBUNIT STRUCTURE: Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. TISSUE SPECIFICTY: Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.SEQUENCE SIMILARITIES: Contains 4 TNFR-Cys repeats. View All» Product Name: Anti-CD265/RANK, clone R12-31 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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