货号：MAB390-25UG

品牌：Merck Millipore

规格：25Ug

目录价：￥1295.00

市场价格：￥1100.75

会员价格：￥1036.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the rat NGF receptor (p75, low affinity Neurotrophin Receptor). MAB365 is the monoclonal antibody used for MAB390-SAP. View All» Immunogen: p75-expressing cells View All» Clone: 192 View All» Isotype: IgG1 View All» Background Information: The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4. Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron's target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons. View All» Species Reactivity: Rat View All» Species Reactivity Note: Rat, not reactive to human or mouse. View All» Non-Reactive Species:

• Human

• Mouse
  View All» Application Notes: Immunohistochemistry (Paraffin): A previous lot of this antibody was used in IH(P).Immunocytochemistry: A previous lot of this antibody was used in IC.Optimal working dilutions must be determined by end user. View All» Control: Brain tissue View All» Purification Method: Protein A purfied View All» Presentation: Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco's PBS with no preservative. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P08138 View All» Entrez Gene Number: NM_002507.2 View All» Gene Symbol:
  • NGFR

  • p75(NTR)

  • TNFRSF16

  • Gp80-LNGFR

  • CD271
    View All» Alternate Names:
    • CD271 antigen

    • Low affinity neurotrophin receptor p75NTR

    • Low-affinity nerve growth factor receptor

    • NGF receptor

    • low affinity nerve growth factor receptor

    • nerve growth factor receptor

    • nerve growth factor receptor (TNFR superfamily, member 16)

    • p75 ICD
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)

      • Affects Function
        View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 25 μg View All» Format: Saporin View All» Host: Mouse View All»
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        © Merck Millipore代理MAB390-25UG Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192;抗-p75 LNGFR抗体，皂草毒蛋白结合，克隆192store at -80℃，产品报价联系微信jinshanbio