Merck Millipore代理MAB3822 Ms X Ezrin

2025-07-23

货号:MAB3822

品牌:Merck Millipore

规格:

目录价:¥3721.00

市场价格:¥3162.85

会员价格:¥2976.80

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-Ezrin Antibody, clone 4A5 | MAB3822 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Ezrin. View All» Immunogen: Ezrin was isolated and purified from gastric parietal cells from rabbit. View All» Clone: 4A5 View All» Isotype: IgG1 View All» Species Reactivity:

  • Canine

  • Human

  • Mouse

  • Rat

  • Rabbit

    View All» Application Notes: Western blot. The antibody recognizes the ~80 kDa Ezrin protein. A breakdown product of ~55 kDa may also be seen depending on sample and concentration used. Immunocytochemistry. Ezrin is periferal membrane protein localized to the cytoplasmic side of microvilli associated with intestinal epithelial cells. The use of fixatives containing gluteraldehyde is strongly discouraged. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: P15311 View All» Entrez Gene Number:
    • NM_001111077.1

    • NM_003379.4

      View All» Gene Symbol:
      • EZR

      • Villin-2

      • VIL2

      • Ezrin

      • MGC1584

      • CVL

      • Cytovillin

      • FLJ26216

      • p81

      • DKFZp762H157

      • CVIL

        View All» Alternate Names: Cytovilli; Villin 2; p81 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • ELISA

        • Western Blotting

        • Immunocytochemistry

          View All» Entrez Gene Summary: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P15311 # Probably involved in connections of major cytoskeletal structures to the plasma membrane.SIZE: 586 amino acids; 69413 Da SUBUNIT: Interacts with MPP5 (By similarity). Interacts with SLC9A3R1 and PACE1.SUBCELLULAR LOCATION: Membrane. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).TISSUE SPECIFICITY: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.DEVELOPMENTAL STAGE: Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.PTM: Phosphorylated by tyrosine-protein kinases.SIMILARITY: SwissProt: P15311 ## Contains 1 FERM domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Ezrin Antibody, clone 4A5 | MAB3822 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»

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