货号：MAB3314

品牌：Merck Millipore

规格：1EA

目录价：￥5125.68

市场价格：￥4356.83

会员价格：￥4100.54

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-16 Antibody, clone 117-10C6 | MAB3314 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody specifically reacts with human MT3-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP). View All» Immunogen: This antibody was made to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP). View All» Clone: 117-10C6 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Immunoblotting View All» Presentation: Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P51512 View All» Entrez Gene Number:

• NM_005941.4

• NM_022564.3
  View All» Gene Symbol:
  • MMP16

  • MMPX2

  • MMP-16

  • MT3MMP

  • MT-MMP3

  • MT3-MMP

  • MTMMP3

  • MMP-X2

  • MT-MMP2

  • EC 3.4.24.-
    View All» Alternate Names: MT3-MMP View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement:
    • Manufactured by Daiichi Fine Chemical Co., Ltd

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. View All» UniProt Summary: FUNCTION: SwissProt: P51512 # Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).SIZE: 607 amino acids; 69521 Da SUBUNIT: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein (Potential). Note=Localized at the cell surface of melanoma cells. & Isoform Short: Secreted. Cell surface. Note=Localized at the cell surface of melanoma cells.TISSUE SPECIFICITY: Expressed in heart, brain, placenta, ovary and small intestine. The short isoform is found in the ovary.DEVELOPMENTAL STAGE: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.DOMAIN: SwissProt: P51512 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: The precursor is cleaved by a furin endopeptidase (By similarity).SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-16 Antibody, clone 117-10C6 | MAB3314 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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