货号：MAB3216-100UG

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TNF Receptor Antibody, extracellular, clone H398 | MAB3216-100ug View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes an extracellular domain of the 55 kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75 kDa TNF receptor (CD120b). This antibody inhibits the biological activity of both natural and recombinant human TNFa and TNFbthrough competitive inhibition of TNF binding to TNF-R1. MAB3216-100ug shows potent antagonistic activity in in vitro TNF mediated cytotoxicity assays (IC50=12nM; IC50=1.7 mg/mL). View All» Molecular Weight: ~50 kDa View All» Epitope: Extracellular Domain View All» Immunogen: Recombinant human tumor necrosis factor receptor type 1 View All» Clone: H398 View All» Isotype: IgG2a View All» Background Information: Tumor necrosis factor receptor superfamily member 1A (TNF-receptor 1 or CD120a) is a receptor for TNFSF2/TNF-alpha. TNF receptor mediates apoptosis and contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain of TNF receptor leads to homotrimerization. Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. View All» Species Reactivity: Human View All» Application Notes: ELISA Flow Cytometry Western Blotting: non reducing conditions only Immunoprecipitation Radioimmunoassay Optimal working dilutions must be determined by the end user. View All» Purification Method: Protein A purfied View All» Presentation: IgG fraction purified from tissue culture supernatant by protein-A affinity chromatography. Liquid in PBS pH 7.4 containing 0.09% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for short term or -20°C up to one year. View All» UniProt Number: P19438 View All» Entrez Gene Number: NM_001065.2 View All» Gene Symbol:

• TNFRSF1A

• TNFR1

• TNF-R1

• TNFR-I

• p60

• CD120a

• p55-R

• TNF-RI

• TNFR60

• TNF-R55

• TNFAR

• TBP1

• TNFR55

• TNF-R-I

• FPF

• TNF-R

• p55

• MGC19588
  View All» Alternate Names: CD120a; TNF-R1; p55 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Flow Cytometry

  • Immunoprecipitation

  • Radioimmunoassay

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. View All» UniProt Summary: FUNCTION: SwissProt: P19438 # Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.SIZE: 455 amino acids; 50495 Da SUBUNIT: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted.DOMAIN: SwissProt: P19438 The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. & Both the cytoplasmic membrane-proximal region and the C- terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity).PTM: The soluble form is produced from the membrane form by proteolytic processing.DISEASE: "SwissProt: P19438 # Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is an autosomal dominant disease characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia."SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-TNF Receptor (CD120a), extracellular, clone H398 View All» Concentration: See datasheet for lot specific concentration. View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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