货号：07-2262

品牌：Merck Millipore

规格：100UL

目录价：￥4553.00

市场价格：￥3870.05

会员价格：￥3642.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-WNK3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~220 kDa observed. Uncharacterized bands appear at ~52 and 60 kDa. View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human WNK3. View All» Background Information: WNK3 is a serine-threonine protein kinase and expressed throughout the nephron, but most commonly at intercellular junctions. In its active state, it is a promoter of NKCC2 and NCC activity. The opposite is true of WNK3 when in an inactive state. WNK3 changes the expression of these transporters in the membrane and is thought to be a regulator of blood pressure along with other members of the WNK family of protein kinases. In recent research, WNK3 has also been linked to regulating signaling cascades involved in tumorigenesis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Other homologies: Rat (74% sequence homology). View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected WNK3 on 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BYP7 View All» Entrez Gene Number: NP_001002838 View All» Gene Symbol:
  • WNK3

  • PRKWNK3
    View All» Alternate Names:
    • WNK lysine deficient protein kinase 3

    • serine/threonine-protein kinase WNK3

    • Protein kinase with no lysine 3

    • Protein kinase lysine-deficient 3

    • protein kinase, lysine deficient 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. View All» UniProt Summary: CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. UniProtKB Q9H4A3COFACTOR: Magnesium (By similarity). UniProtKB Q9H4A3ENZYME REGULATION: Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes increased activity By similarity. UniProtKB Q9JIH7TISSUE SPECIFICITY: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.Contains 1 protein kinase domain.CAUTION: Cys-176 is present instead of the conserved Lys which is expected to be an active site residue. Lys-159 appears to fulfill the required catalytic function. UniProtKB Q9JIH7 View All» Product Name: Anti-WNK3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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