货号：340426

品牌：BD IS

规格：100T

目录价：￥5707.00

市场价格：￥3994.90

会员价格：￥3709.55

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Catalog Number

340426

Name

CD26

Size

50Tests

RegulatoryStatus

RUO (GMP)

Clone

L272

Format

FITC

Isotype

IgG_2a, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD26 recognizes a 120-kDa antigen that is identical to the enzyme dipeptidyl peptidase (DPP), a serine protease. It is associated with the binding of the TAT transactivating protein of the human immunodeficiency virus (HIV). CD26 and CD45 act in a co-stimulatory fashion on T lymphocytes.Present on peripheral blood T lymphocytes, the CD26 antigen is upregulated on PHA- and Con A-stimulated peripheral blood mononuclear cells (PBMCs). The CD26 antigen is found on approximately 50% of CD4 and approximately 30% of CD8 cells. It is also found on EBV-transformed B-cell lines, hairy-cell leukemia, and macrophages. Absolute numbers of CD4⁺CD26⁺ and CD8⁺CD26⁺ cells are reported to be lower in HIV-positive individuals. The CD26^-CD4⁺ cell appears to be a reservoir for HIV. CD26-bright CD4 lymphocytes are CD25⁺ and CD45RO⁺ memory T lymphocytes.