货号：700635

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This monoclonal antibody is validated to react with human ERBB2 [pY1248] and has expected reactivity with mouse, rat, rhesus monkey, feline, canine, frog, and chicken ERBB2 [pY1248]. It is validated for use in Western Blots. erB-2 [pY1248] is encoded by the 2064 gene, also known as NEU; NGL; HER2; TKR1; CD340; HER-2; HER-2⁄neu. ERBB2, a 185 kDa transmembrane protein, is one of four ERBB receptor tyrosine kinases belonging to the Epidermal Growth Factor Receptor (EGFR) family (1). These receptor tyrosine kinases play an important role during cardiovascular and nervous system development (2-3). In both cardiovascular and nervous system development, cell communication and signaling require ERBB family proteins and overexpression of ERBB2 has been found in a variety of human cancer models (2-3). ERBB receptor tyrosine kinases have an extracellular domain involved in ligand binding and receptor homo- or heterodimerization (1). ERBB2 has also been shown to be the preferred receptor for heterodimerization with the other three ERBB proteins (1).References1. Birchmeier C (2009) ErbB receptors and the development of the nervous system. Exp Cell Res. 4: 611-18.2. Muthuswamy SK et al (1999) Controlled dimerization of ErbB receptor provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 10: 6485-57.3. Pentassuglia L and Sawyer DB (2009) The role of Neuregulin-1beta⁄ErbB signaling in the heart. Exp Cell Res. 4: 627-37. 规格

Reactivity:	Human
Validated Application:	Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	40H87L57
Antibody Fragment:	Whole Antibody
Target Gene:	erbB-2 [pY1248]
Target Molecule:	Proteins (Phosphoproteins)
Gene ID:	2064
Gene Symbol:	ERBB2
Accession Number:	P04626
Label or Dye:	Unconjugated
Target Modification State:	Phospho
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Form:	Liquid
Mass:	100 µg
Neutralizing Antibody:	No
Product Size:	100 µg
Protein Family:	Growth Factors & Receptors
Quantity:	1 each
Volume:	200 µl
Research Category:	Signal Transduction
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.